Stimulate Your Own
Growth Hormone Axis.
CJC-1295 and Ipamorelin trigger natural, pulsatile GH release from your own pituitary — no synthetic hormones, no suppression, no post-cycle therapy. IGF-1 LR3 amplifies the downstream anabolic signal directly in muscle tissue.
The Complete GH/IGF-1 Axis — Step by Step
GHRH analog — binds GHRH receptors in the hypothalamus, triggering GnRH release
Ghrelin mimetic — amplifies the GH pulse at the pituitary without cortisol or prolactin release
Natural pulsatile GH release — 200–300% above baseline at peak, preserving circadian rhythm
GH drives hepatic IGF-1 production — primary downstream anabolic signal to muscle tissue
Modified IGF-1 with 13× longer half-life — amplifies satellite cell activation and muscle hyperplasia directly
GH Peptides vs. Anabolic Steroids
Why performance athletes favor secretagogues for sustainable long-term gains.
| Factor | GH Peptides | Anabolic Steroids |
|---|---|---|
| HPTA suppression | None | Severe |
| Post-cycle therapy | Not required | Mandatory |
| Estrogen conversion | None | Common |
| Liver strain | None | Oral anabolics only |
| Blood pressure impact | Minimal | Elevated |
| Natural GH maintained | Yes (pulsatile) | Often suppressed |
Injection Timing Protocol
Pre-sleep (11pm)
CJC-1295 + Ipamorelin injection
Aligns with natural GH pulse amplitude peak during slow-wave sleep
Upon waking (fasted)
IGF-1 LR3 injection (cycle days)
Maximum satellite cell sensitivity when insulin is low and GH still elevated
Post-workout
IGF-1 LR3 alternative timing
Elevated nutrient partitioning — IGF-1 directs amino acids to muscle, not fat
Cycle structure: 12–16 weeks CJC-1295/Ipa on → 4 weeks off. IGF-1 LR3: 4–6 weeks on → 4 weeks off. No PCT required for either compound.
2 performance peptides
GH secretagogues and IGF-1 axis amplifiers
CJC-1295 / Ipamorelin
The gold standard GH stack — pulsatile growth hormone release without cortisol or prolactin elevation
IGF-1 LR3
Long R3 IGF-1 — promotes muscle hyperplasia and satellite cell activation for permanent muscle fiber growth
Related Protocols
CJC-1295 / Ipamorelin
The gold standard GH secretagogue stack — pulsatile, clean, effective.
IGF-1 LR3
Downstream anabolic signal for permanent muscle fiber growth.
GH Optimization Stack
The complete growth hormone axis protocol.
Elite Performance Stack
GH peptides + IGF-1 LR3 + BPC-157 for elite training performance.