fat loss
Quality Rating
Buy Tesofensine 500mcg x30 Capsules
Triple monoamine reuptake inhibitor — potent appetite suppression and metabolic rate increase
10.6% weight loss Phase 2Best-in-class oral agentTriple monoamine inhibition
Who This Is For
Users wanting the most potent oral fat loss compound available, or those combining with GLP-1 agonists for additive appetite suppression from different pathways.
Overview & Benefits
Tesofensine was originally developed as a Parkinson's treatment but pivoted to obesity when Phase 2 trial participants showed remarkable weight loss: 10.6% at 0.5mg/day over 24 weeks — the highest weight loss from a CNS-acting oral agent in Phase 2 trials at that time. Its mechanism combines appetite suppression via monoamine reuptake inhibition with mild sympathomimetic metabolic rate increase.
Unlike GLP-1 agonists which act peripherally, Tesofensine's CNS mechanism means it suppresses appetite through reward and satiety circuitry — complementary rather than redundant with GLP-1 pathways. Side effects are predominantly sympathomimetic (increased heart rate, mild blood pressure elevation, dry mouth) and diminish over 2–4 weeks as tolerance develops.
Key Benefits
- 10.6% weight loss at 0.5mg/day in Phase 2 — best-in-class oral agent result
- Triple monoamine reuptake inhibition suppresses appetite via CNS reward and satiety circuits
- Mild metabolic rate increase alongside appetite suppression
- CNS mechanism is complementary and additive to GLP-1 agonists
- Once-daily oral dosing — no injection required
Protocols & Dosing
Standard 30-Day Protocol
Once daily in the morning0.5mg oral capsule
Take in the morning to avoid sleep disruption. Expect mild increased heart rate for first 2 weeks. Do not combine with MAOIs or other serotonergic compounds.
Buy Tesofensine 500mcg x30 Capsules
$99.99
Buy Now — $99.99Buy at PhiogenResearch-grade · COA verified · Phiogen
Categoryfat loss
Typeoral
Quality Rating★★★★☆
VendorPhiogen
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Tesofensine 500mcg x30 Capsules
$99.99