Mazdutide 6mg
fat loss
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Buy Mazdutide 6mg

GLP-1/Glucagon dual agonist — potent fat loss with thermogenic glucagon component

Dual GLP-1/Glucagon14.5% weight loss Phase 2Thermogenic advantage

Who This Is For

Users seeking more fat loss potency than semaglutide but wanting to step toward dual agonism before committing to retatrutide.

Overview & Benefits

Mazdutide (IBI362) combines GLP-1 receptor agonism for appetite suppression with glucagon receptor activation for increased thermogenesis and hepatic fat oxidation — the same dual-agonist concept that makes retatrutide more potent than semaglutide, without the GIP component. Phase 2 data in Chinese populations showed 14.5% body weight reduction at 9mg weekly, with strong visceral fat reduction and lipid improvements. The glucagon component is what differentiates dual agonists from pure GLP-1s: it activates brown adipose tissue, increases basal energy expenditure, and promotes hepatic fat clearance. For users who have plateaued on semaglutide or want more thermogenic activity than pure GLP-1 provides, Mazdutide represents the intermediate step toward triple-agonist territory.

Key Benefits

  • Dual GLP-1/Glucagon agonism for appetite suppression plus thermogenesis
  • 14.5% body weight reduction in Phase 2 trials
  • Brown adipose tissue activation drives energy expenditure beyond GLP-1 alone
  • Strong visceral fat and hepatic fat reduction
  • Intermediate potency between semaglutide and retatrutide

Protocols & Dosing

Weekly Titration Protocol

Once weekly
Start 1mg, titrate to 3–6mg over 8–12 weeks

Slower titration than semaglutide due to glucagon component GI effects. Monitor for nausea and ensure adequate protein intake.

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Mazdutide 6mg

Buy Mazdutide 6mg

$129.99

Buy Now — $129.99Buy at Phiogen

Research-grade · COA verified · Phiogen

Categoryfat loss
Typeinjectable
Quality Rating★★★★☆
VendorPhiogen

Mazdutide 6mg

$129.99

Buy Now