
fat loss
Quality Rating
Buy Mazdutide 6mg
GLP-1/Glucagon dual agonist — potent fat loss with thermogenic glucagon component
Dual GLP-1/Glucagon14.5% weight loss Phase 2Thermogenic advantage
Who This Is For
Users seeking more fat loss potency than semaglutide but wanting to step toward dual agonism before committing to retatrutide.
Overview & Benefits
Mazdutide (IBI362) combines GLP-1 receptor agonism for appetite suppression with glucagon receptor activation for increased thermogenesis and hepatic fat oxidation — the same dual-agonist concept that makes retatrutide more potent than semaglutide, without the GIP component. Phase 2 data in Chinese populations showed 14.5% body weight reduction at 9mg weekly, with strong visceral fat reduction and lipid improvements.
The glucagon component is what differentiates dual agonists from pure GLP-1s: it activates brown adipose tissue, increases basal energy expenditure, and promotes hepatic fat clearance. For users who have plateaued on semaglutide or want more thermogenic activity than pure GLP-1 provides, Mazdutide represents the intermediate step toward triple-agonist territory.
Key Benefits
- Dual GLP-1/Glucagon agonism for appetite suppression plus thermogenesis
- 14.5% body weight reduction in Phase 2 trials
- Brown adipose tissue activation drives energy expenditure beyond GLP-1 alone
- Strong visceral fat and hepatic fat reduction
- Intermediate potency between semaglutide and retatrutide
Protocols & Dosing
Weekly Titration Protocol
Once weeklyStart 1mg, titrate to 3–6mg over 8–12 weeks
Slower titration than semaglutide due to glucagon component GI effects. Monitor for nausea and ensure adequate protein intake.
Stack With These Peptides

Buy Mazdutide 6mg
$129.99
Buy Now — $129.99Buy at PhiogenResearch-grade · COA verified · Phiogen
Categoryfat loss
Typeinjectable
Quality Rating★★★★☆
VendorPhiogen
Mazdutide 6mg
$129.99

